Development tools for Zephyr on STM32Workbench for Zephyr: VS Code extension to set up, build, flash and debug Zephyr applications on STM32.Devicetree manager: browse, edit and visualize Zephyr devicetree, STM32CubeMX-like for Zephyr.
You can change the board and the mcu in Properties > C/C++ Build > Settings > Target tab. But as you said, the symbols and dependencies need to be changed by youself.